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5 Prediabetes is a significant risk factor for DN, with the prevalence of DPN among prediabetes individuals ranging from 6 to 25%

It readily crosses the blood-brain barrier, influencing neurotransmitter synthesis and release, enhancing synaptic function, and promoting nerve cell regeneration

Two different studies found that patients who followed a program of increased physical activity (150-175 minutes of exercise per week), weight loss (sustained loss of 7% of their body weight), and a low-calorie, low-fat diet had lower blood pressure and triglyceride levels, suggesting that these lifestyle changes could help prevent diabetic neuropathy (Diabetes Prevention Program Research Group 2005