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Glutathione is synthesized in the cytosol of all cells from their precursor amino acids: glutamic acid, cysteine and glycine by consecutive action of two enzymes: -glutamyl-cysteine (-GluCys) synthetase (also known as glutamate cysteine ligase, GCL) that in a first step uses glutamate and cysteine as a substrate to form the dipeptide -glutamyl-cysteine

It incorporates itself into the lipid bilayer of the mast cell membrane, altering its fluidity and making the cell significantly less prone to degranulation

All these data indicate that lactate promotes the stemness potentials in detached ER + breast cancer cells

doi: 10.3906/sag-1704-142