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The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

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Although it is generally safe to assume that covalent inhibitors bearing a thiol-reactive electrophile will target the nucleophilic catalytic cysteine residue, covalent modification of less reactive cysteines [70,91], or even unexpected amino acids, has been reported in exceptional cases [71]