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Lip freckle, sun spot on the lip, age spot on the lip, and labial melanotic macule are often used interchangeably to describe the same type of benign pigmented lesion
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MC4R activation in renal tubular epithelium increases water reabsorption through aquaporin-2 channel upregulation, producing mild fluid retention (0.51.5 kg weight gain) in 812% of subjects over 714 days of repeated dosing
