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The other drawback is that some people who are sensitive to higher histamine levels or who have mast cell activation syndrome report that NAC gives them a histamine reaction

Rinna, Glutathione: overview of its protective roles, measurement, and biosynthesis
This effect is enhanced when combined with Vitamin C, which boosts glutathione absorption

17 Mechanistically, competition strategies among bacteria that produce antibiotics and small metabolites like phenazines that limit the growth of other bacterial species may have off-target effects on mitochondrial homeostasis, leading to ROS, protein damage, and neurodegeneration
