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As our comprehension of cancer genomics expands, clinical trials are increasingly tailored to individual patients, often based on the unique biology of their tumors

The ability to acquire choline and amino acids from the diet and to salvage the purine nucleotides makes the role of 5,10-methylene-THF, in dTMP synthesis, one of the most significant metabolic functions for dietary folate

These tissues were subjected to biochemistry or immunohistochemistry

The authors argue that this is a missed opportunity because the TDLN is a place where tumor antigens are first processed and presented to the immune system, and where the balance between immune activation and immune tolerance may be decided early