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Therefore, it is necessary to explore the correlation between MTHFR gene polymorphisms and serum folate levels and CRC risk, and to verify that MTHFR gene variants are one of the genetic susceptibility factors of CRC, which can help to provide a reference for personalized diagnosis and treatment and provide a new idea and direction for targeted therapy

10.3389/fmicb.2021.680749 [DOI] [PMC free article] [PubMed] [Google Scholar] 220.Ashu EE, Korfanty GA, Samarasinghe H, Pum N, You M, Yamamura D, et al