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POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

For vitiligo patients, the risk gets extra sneaky around melanin peptides like melanotan II, because pigment is emotional and the marketing knows it

Lucarini E, Micheli L, Toti A, et al