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Moreover, presynaptic and postsynaptic dopaminergic abnormalities have been linked to the onset of mental illness, with the dysregulation of the dopaminergic system being one of the main culprits in the etiology of schizophrenia [124]

These pain-relieving effects are blocked by drugs that affect norepinephrine, but not serotonin, suggesting that the pain relief works through adrenergic pathways (9)

Toradol, also known by its generic name ketorolac tromethamine, is a nonsteroidal anti-inflammatory drug (NSAID) 1 widely recognized for its potent pain-relieving and anti-inflammatory properties

In contrast, modification with HPDP-biotin maintained a stable closed state for over 16 weeks at the same temperature (Supplementary Fig