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This bidirectional relationship is clinically evident in the early elevation of OS biomarkers (e.g., urinary 8-OHdG, serum F2-isoprostanes) preceding overt DM and their correlation with disease severity and complications (e.g., retinopathy, nephropathy)

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[27] found no significant effects of citrulline on arm lean mass (LM), arm strength, leg strength, leg LM, and Appendicular Lean Mass Index (ALMI)
