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In acid sphingomyelinase knock-out mice, which mimic a neurovisceral acid sphingomyelinase deficiency (ASMD) characterized by cellular accumulation of sphingomyelin, the effects of a choline-free diet decreased the activation of liver macrophages and microglia, but it did not significantly alter sphingomyelin levels due to compensatory mechanisms involving methionine metabolism (101)

We found that 24 h of pre-treatment with ALCAR (1 and 10 mM), resulted in inhibited adhesion of PC-3, DU-145, LNCaP and BPH cells on a fibronectin layer, in a concentration-dependent manner (Fig

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