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Why that selectivity exists at the receptor level isnt entirely settled it may reflect biased agonism, where the specific binding geometry favors the somatotroph signaling pathway over the corticotroph one, even though both cell populations express GHSR-1a

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Investigators in the DANAMI-3-iPOST trial 113 assessed the effect of ischaemic postconditioning on all-cause mortality and hospitalization for heart failure (composite primary end point) in 1,234 patients with STEMI undergoing percutaneous coronary intervention (PCI)