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Genes involved in oxidative stress and ferroptosis modulate sensitivity, with GPX4 as the top sensitiser in both screens
Mold-induced inflammation overactivates this system, leading to dysregulation
Upon binding of both O 2 and NADPH to CuSAE, NADPH is oxidized to NADP + by donating electrons to the CuSAE, through which O 2 acquires electrons and forms O 2 - radicals
In adults, these can lead to different diseases, from cancer and amyotrophic lateral sclerosis to Parkinson's disease (153155)
