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10.1016/j.arr.2018.10.010 103 ParsonsR
Ulanovskaya OA, Zuhl AM, Cravatt BF
Enter etanercept (Enbrel), the first drug approved by the U.S
At the enzyme level, 5-Amino-1MQ inhibits NNMTs methylation of nicotinamide reducing intracellular 1-MNA levels and diverting nicotinamide back into the NAD+ salvage pathway (via NAMPT-mediated conversion to NMN and subsequently NAD+)
