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Additionally, metallic elements, including chromium, nickel, and lead, are released from the devices heating coils during aerosolization, introducing additional hepatotoxic risk [122]

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Dingman R and Balu-Iyer SV, Immunogenicity of Protein Pharmaceuticals

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doi: 10.3389/fimmu.2025.1635736 Received 27 May 2025 Accepted 24 October 2025 Published 05 November 2025 Volume 16 - 2025 Edited by Nisha Jain Garg, University of Texas Medical Branch at Galveston, United States Reviewed by Carolina Dalmasso, University of Kentucky, United States Suman Asalla, The Ohio State University, United States Updates Copyright 2025 Zhao, Yang, Lin, Lei, Ding, He, Cao, Zhang, Liu, Liang, Han and Jiang