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This finding supports the tandem use of anti-CD38 antibodies and PD-1/PD-L1 checkpoint blockers to enhance the immune response to cancer, thereby providing a two-pronged approach to immunomodulation of the tumor microenvironment

Approaches using radiolabeled anti-CD38 conjugates have resulted in high tumor-to-normal organ ratios and reduced toxicity and sdAb#2F8 labeled with therapeutic radionuclides confirmed its potential as theranostic tools (Fig