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For the health of the general population, the subtle changes in insulin, GH and IGF-I signaling associated with gene polymorphisms or epigenetic changes programmed during fetal and early postnatal life and affecting gene expression are important

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Recent solution NMR structural studies have provided detailed molecular models of the p53 transactivation domain in complex with both the FOXO4 forkhead domain and FOXO4-DRI, advancing understanding of the precise molecular interactions that enable selective senescent cell targeting in research applications