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We detected an increase in IFN- producers and triple IFN-/TNF/IL-2 producers (Figure 7, I and J, and Supplemental Figure 7D) in CMV-specific CD8 + T cells from noncontrollers, whereas no effects were observed in controllers

When NNMT activity is reduced, cells can more efficiently utilize nicotinamide adenine dinucleotide (NAD+), leading to enhanced mitochondrial function and improved metabolic flexibility

The peptides discussed are sold as research chemicals and are not approved by Health Canada for human therapeutic use

Therefore, therapies combined with other treatments are considered helpful to maximize CD38 mAb effects against MM