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Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases

Use in Local Nasal Conditions: Utilizing nasal spray TB-500 while experiencing a local nasal condition may jeopardize systemic absorption

These typically improve after reaching stable maintenance doses

The patient-reported benefit is real but confounded
