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Acknowledgements We are grateful to Shon Lenzo and Richard A
In addition, macrophages contribute to renal fibrosis by producing ROS and metalloproteinases (58)
In the pathogenesis of hypothyroidism, especially autoimmune subtypes such as Hashimotos thyroiditis, gut microbiota plays a key role in the regulation of body immune homeostasis, affecting the occurrence and development of hypothyroidism through a series of complex mechanisms (Virili et al., 2018)
In addition, hepatic ischemiareperfusion injury may affect the pancreas by circulating the inflammatory mediators released from the liver
