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These findings are complemented by the identification of several single-nucleotide polymorphisms (SNP) in GKRP, the protein that inhibits and sequesters GCK during fasting, that strongly associate with lower fasting glucose and insulin resistance coupled with increased blood and liver TAGs (243, 296)
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Mutants and redheads showed an increased analgesic response, which the authors confirmed was likely a true pharmacodynamic, rather than metabolic/pharmacokinetic effect, as circulating levels of the drug were similar in both groups [27]
Rodriguez, Fausto J., Andrew L
