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All three RAMPs can interact with CTR, and this gives rise to three discrete Amy receptor phenotypes, AMY 1 R, AMY 2 R and AMY 3 R, with RAMP1, RAMP2, and RAMP3, respectively 7,8
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The incidence is relatively low, affecting less than five percent of patients with pre-existing retinopathy, but regular ophthalmologic monitoring is recommended for patients with diabetes-related eye disease
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