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negevensis SnCE2-5 (UniProt: F8L8N5, F8L3F3, F8L927, F8L668) were expressed as fusion proteins with N-terminal His 6 -Smt3-tag using the pOPIN-S vector enabling tag cleavage by human sentrin-specific proteases (SENP)
Consistent with current knowledge of STAT3 function within the SAFE pathway, the ambivalent role of STAT3 in myocardial IRI is evident, exhibiting a protective effect when activated in the early phases of reperfusion and a detrimental effect in the later stages [37, 104]
