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Upon binding, these complexes activate Gs-coupled intracellular signalling cascades, leading to adenylyl cyclase stimulation, elevated cyclic AMP (cAMP) production, and downstream activation of protein kinase A (PKA)
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Additionally, the FOXO4-p53 interaction contributes to the maintenance of senescent cells by activating the transcription of their common target gene, p21cip1, which suppresses apoptosis 36
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