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KEAP1, as an E3 ligase, negatively regulates NRF2 level

131 , 132 In an experimental model, quercetin was shown to reduce the expression of M1 microglia and their pro-inflammatory mediators while promoting the upregulation of M2 cells and enhancing the anti-inflammatory response

Dietary zeolite supplementation reduces oxidative damage and plaque generation in the brain of an Alzheimer's disease mouse model

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