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The fact that sustained stimulation of the same receptor may result in different degrees of tolerance for distinct behavioural responses is highly reminiscent of observations obtained in neuronal cultures where signalling regulation was found to be cell- and effector-specific

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10.1371/journal.pone.0086686 70 SaagaM.MosiskaP

In such bilateral studies, the consistent therapy findings on both injured eyes may be a particular confirmation of the applicability of the effect
