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Elevated aldosterone levels also downregulate insulin receptor expression and signaling pathways, contributing to insulin resistance by impairing glucose transporter type 4 translocation and reducing glucose uptake in peripheral tissues

Thus, targeting bioavailable forms of iron via iron chelation in an energy-deprived context could weaken ferroptosis defences, which would explain the paradoxical clinical worsening in iron chelator trials [33,34]

This is indicative of an insect adaptive mechanism against oxidative stress generated by the plant-derived toxic chemical substances [54, 133], suggesting many GSTs are responsible for protecting tissues and reducing the mortality rate of insects caused by oxidative stress

M.van GoethemE.MllerA