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30 The activation of genes responsible for antioxidant defense (e.g., the glutathione (GSH) system, 8 coenzyme Q10 (CoQ10) system, 31,32 and the nuclear factor, erythroid 2-like 2 (NFE2L2, also known as NRF2) transcription pathway 33 ) and membrane repair (e.g., the endosomal sorting complexes required for transport (ESCRT)-III pathway 34 ) limit membrane damage during ferroptosis (Fig

In addition to nucleotide biosynthesis, the nitrogen of glutamine in mammalian cells is also required to synthesize NAD, glucosamine6phosphate, a precursor for protein glycosylation, and asparagine, another nonessential amino acid (Richards & Schuster, 1998

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