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F1000Research 2020, 9 , F1000 Faculty Rev-69

Sinovac (China) Sinovac opened Phase III trials of its vaccine candidate, CoronaVac, in July

Unlike fat-soluble vitamins, vitamin B12 is water-soluble, meaning excess amounts are typically excreted through urine

Plausible degradation pathways include: Serum aminopeptidases (cleaving from the N-terminus) Endopeptidases (internal bond cleavage) Hepatic uptake and degradation Renal clearance (though direct renal excretion of intact peptide of this size is typically limited) Whether BPC-157 generates active metabolites i.e., smaller peptide fragments that retain biological activity is not established in the public literature