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The intestinal microbiota of adolescents appears to be in an intermediate stage of development in terms of taxonomic composition, as shown by the high relative abundance of bacteria such as Bifidobacterium and Bacteroides fragilis , which are highly abundant in infants and toddlers (Hopkins et al., 2001
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This explicit requirement for lipid peroxidation is a core feature of ferroptosis that distinguishes it from other forms of cell death: ferroptosis inhibitors cannot prevent other forms of cell death (Yang et al., 2014), and conversely classic inhibitors of necrosis, apoptosis, and autophagy do not modulate ferroptosis ( Figure 1 )
