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Int J Parasitol 39(2):213220 [cited 2024 Apr 8]

It attacks the hydrogen atom of an amino acid residue to form a carbon-centered radical that reacts with oxygen to generate an alkyl-peroxyl radical and then in two steps an alkoxyl radical

This multifunctional design allows DOX and MPI to collaboratively induce significant ICD, serving as a stimulatory offense signal to augment CD 8+ T-cell infiltration, while the siTOX component offers a complementary defense signal by downregulating TOX expression, thus mitigating T-cell exhaustion

356,360,361,362 Disruption of the BBB may also lead to ischemic/hypoxic brain damage and increase A production