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doi: 10.1007/s40199-023-00458-y 90
Among the mechanisms that determine disease severity, immature molecular response and defense systems at the intestinal epithelial cell (IEC) are implicated
In loss-of-function studies, CBX3 knockdown inhibited GSC growth and sphere formation in vitro (Supplemental Figure 5, IL), suggesting that CBX3 has tumor cell-autonomous tumorigenic actions
While the liver and kidneys handle most detoxification, the skin provides a secondary route, and increased sweating can reduce overall toxin burden
