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An alternative approach, also called indirect, involves interaction with transcription factors, including TF, AP-1, SP1, and NF-B, which recruits chromatin-modifying coregulator proteins and enables activation or repression of ER target genes to direct cell proliferation (208)

Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D

It plays a vital role in: Mitochondrial energy production (ATP synthesis) DNA repair and gene expression Cell signaling and metabolism As we age, NAD levels naturally decline , leading to fatigue, reduced cellular function, slower metabolism, and neurodegeneration

The implantation of mini-SNLSs in 6-OHDA-induced rat models of PD significantly reduced dyskinesia (Fig