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TBI could be related to head injuries sustained in combat, equestrian, military training, falls, sports (contact and solo), shock wave exposures (single or multiple small), bicycle and motor vehicle accidents

Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]

Ann Med