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Recently, Chen et al (187) developed a folic acid-decorated, manganese dioxide-coated mesoporous silica nanoparticle to co-deliver fluvastatin sodium (MCT4 inhibitor) and metformin, effectively targeting tumor lactate metabolism by promoting lactate production and inhibiting lactate efflux, thereby exacerbating intracellular acidosis and inducing cancer cell death

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Lipid peroxidation damages mitochondrial membranes and disrupts mitochondrial function, leading to insufficient energy supply in muscle cells, which exacerbates muscle atrophy and the onset of sarcopenia ( Mitochondria are major sources of free radicals, and lipid peroxidation exacerbates oxidative stress by increasing the generation of reactive oxygen species (ROS), damaging mitochondrial membranes and DNA, and weakening repair capabilities

As an inhibitor of nicotinamide N-methyltransferase (NNMT), 5-Amino-1MQ helps shift the body away from energy conservation and toward increased metabolic activitysupporting fat reduction while preserving lean tissue