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Cardiomyocytes in CAD patients exhibit particular vulnerability to ferroptosis under adverse conditions such as ischemia and hypoxia, leading to cellular dysfunction and compromised cardiac performance ( However, research on ferroptosis mechanisms in CHD remains in its nascent stages, with numerous crucial questions awaiting resolution

**Since the serum creatinine (SCr) hasn't spiked yet, you are the "early warning system" that prevents subclinical damage from becoming permanent stage 3 AKI

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Treatment by cyclosporine A resulted in relatively higher interstitial fibrosis and kidney damage in Nrf2/ mice (Liu M