n acetylcysteine precursor to glutathione The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species What is NAC? | Axon

In addition to the availability of authentic ferroptosis inducers such as erastin (system Xc inhibitor) and RSL3 (GPX4 inhibitor), there are several reliable ferroptosis inhibitors

For instance, drug exposure drives the phenotypic alterations of tumor cells, including dedifferentiation, EMT or trans-differentiation, marked by upregulated EMT-related transcriptional factors (TFs), including Zinc finger E-box binding homeobox 1 (ZEB1), ZEB2 and SLUG, that suppress pro-apoptotic proteins (BIM, BMF) and activate anti-apoptotic proteins (Bcl-xL, BCL- 2, MCL1) [38,39,40]

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