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Description
Intranasal administration of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, enhances total uptake and bioavailability in Swiss Webster mice when compared to intraperitoneal, subcutaneous, and intramuscular delivery systems
Initial weight loss may occur within the first month, with more noticeable results developing over several months
28 To assess for inflammation, a standard C-reactive protein (CRP) can be included
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