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Activation of integrin receptors in PMNs leads to a signaling cascade that results in the phagocytosis of extracellular pathogens, as well as in superoxide burst (Williams and Solomkin, 1999)

At the same time, OS can promote the proliferation of theca-interstitial cells, upregulate CYP17, reduce serum SHBG levels, increase androgen secretion, improve the biological activity of serum free testosterone, and cause HA

This bidirectional crosstalk has been shown to contribute to the development of neurodegenerative diseases and increase neuroimmune dysfunction in the presence of toxicants (Skaper et al., 2017

PRLX93936, an elastine analogue, can induce lipid peroxidation and ferroptosis in lung cancer cells when combined with CDPP