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Cathepsin C inhibitors: property optimization and identification of a clinical candidate

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In addition, N-acetylcysteine inhibits von Willebrand factor dependent platelet aggregation and collagen binding in human plasma and in mice[207], attenuates MMPs expression in microvascular endothelial cells and in rats[202,208], and inhibits caveolin-1 upregulation and improves endothelial barrier function in mice[209], which may also contribute to the endothelial protective effect of N-acetylcysteine

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