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While the absolute level of estrogen is less in the body, her cells are exposed to excessive estrogen due to the severe deficiency of progesterone during menopause
As a result, the increased secondary BAs can activate TGR5, which increases L-cells and GLP-1 secretion by inhibiting the RhoA/ROCK pathway and inducing YAP activation [157, 203]
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10.1016/j.neuron.2017.11.026 192 SchultzV.van der MeerF.WrzosC.ScheidtU.BahnE.StadelmannC.et al
