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Junctional Adhesion Molecule The JAM family belongs to the Ig superfamily and is characterized by 2 extracellular Ig domains, one transmembrane domain, and one intracellular C-terminal domain.31 The extracellular N-terminal domains of the JAM family members bind to various ligands through hemophilic and heterophilic interactions.32 The hemophilic interactions involving the JAM members have a role in the formation of TJs and the cell-cell border

and (III) increasing the mitochondrial buffering (Ward et al., 1999)

However, the clinical translation of these treatments still faces significant challenges, particularly regarding how to selectively modulate these pathways without interfering with other metabolic processes

This phase keeps building up B12 stores and helps with recovery