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Additionally, curcumin restored p15INK4b expression by hypomethylation of its promoter inducing cell cycle arrest at G1 phase and apoptosis in vitro (Yu et al., 2013)

Serum levels of cytokines assessed included Flt-3L (FMS-like tyrosine kinase 3), IFN-, TNF-, IL-4, IL-6, IL-8, IL-12, IL-13, IL-18, and MCP-1 (monocyte chemotactic protein 1 or CCL2)

Further validation may involve in vivo models and correlation with patient data to assess clinical relevance and predictive potential