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[DOI] [PubMed] [Google Scholar] 25.Barraclough, R

Medication-induced nephrotoxicity There is a steady, exponential increase in medication-induced nephrotoxicity with special emphasis on antimicrobial therapy at a time of increasing pharmacological resistance in the case of severe bacterial infections

doi: 10.1016/j.chom.2012.10.014 46 ButcherLDden HartogGErnstPBCroweSE

Compounds such as allicin, diallyl disulfide (DADS), diallyl trisulfide (DATS), and ajoene exert broad-spectrum antimicrobial activity by oxidizing lowlow-molecular-weight thiols (e.g., glutathione) and disrupting protein thiol networks essential for DNA synthesis, respiration, and quorum sensing (Nakamoto et al., 2020)