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When SAMe is low, the remethylation of homocysteine to methionine is prioritized in the cell (instead of the transsulfuration pathway).[ref] Drains on methyl groups: About 40% of methyl groups are used for creatine synthesis, so when creatine levels are higher, it can reduce the need for methyl groups

Research-chemical and gray-market sourcing introduces serious problems: the actual identity and purity of the product may be unverified, sterility is not guaranteed, and labeled contents may not match what is in the vial

doi: 10.3389/fimmu.2021.651191