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There's no first-pass metabolism issue, no gut enzyme exposure, no uncertainty about what percentage of the dose actually reaches target tissue

Lipid nanoparticles (LNP) with mRNAs were injected into the tail vein of model animals at postoperative 7 and 14 days after tracheal administration of bleomycin

10.22203/ecm.v021a40 276 SugimotoY.TakimotoA.AkiyamaH.KistR.SchererG.NakamuraT.et al (2013)

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