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To become active again, it needs to be "reduced" (recharged) by other nutrients
doi: 10.1136/bmj-2022-070762 127 SudburyJ
Transsulfuration also allows the thioether-associated S in Met to be transferred to Cys and Cys-based metabolites without disulfide reduction or consumption of NADPH (discussed above)

Male Mc4r- KO mice were kept on a HFHS diet for 9 weeks and the mice were 17 weeks old at study start (The Jackson Laboratory, 032518)
