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The Bcl-2 family, comprising both anti-apoptotic proteins (like Bcl-2 and Bcl-xl) and pro-apoptotic proteins (like Bax and Bak), governs apoptosis primarily by modulating mitochondrial permeability

Nanodelivery co-delivery system (NDCDS) allows two active substances to be encapsulated in the same nanocarrier, delivered simultaneously to the tumor site, and released in a designed ratio and time sequence, resulting in synergistic effects within the tumor cells (255)

10.3389/fmicb.2022.947112 31 LiuY.YuX.ZhaoJ.ZhangH.ZhaiQ.ChenW

The construct was transfected with packaging and envelope vector into HEK 293T cells to create lentivirus (Fig