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Higher doses up to 30g have been used in research for specific conditions like schizophrenia, but such amounts should only be taken under medical supervision, as at these doses, opposing data has been found

Letter to the Editor Regarding Effectiveness of Mentorships and Early Exposure in Neurosurgery

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Safety In l-ARG and placebo groups, no significant changes were detected from T0 to T1, regarding clinical and biochemical parameters, except for HDL cholesterol levels, which were significantly increased in l-ARG group ( p = 0.001) and decreased in placebo group ( p = 0.0001)