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We hypothesize that the lactate-H3K18la epigenetic axis, the TREM2-SHP1-BTK signaling pathway and itaconate-mediated mitochondrial modulation regulatory nodes in sepsis can function as synchronous elements rather than isolated metabolic changes (25,68,189,190)

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Concentrations in PBS were 100-fold lower than those used for MIC testing, at 1128 mg/L, whereas those in CAMHB were identical to the ones used in MIC testing, ranging 10012,800 mg/L

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